[Epigenetic modification of the genetic material. Genomic imprinting and its significance for disease in human beings].

Abstract excerpt

Genomic imprinting is the epigenetic differential marking of maternally and paternally inherited alleles of specific genes or chromosomal subregions during gametogenesis, leading after fertilization to differential expression during development. Expression is thus monoallelic, with one parental allele being expressed, the other silenced. Imprinting implies the existence of a reversible imprinting signal, which is...

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