Article
Epigenetics and human disease: translating basic biology into clinical applications.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne - 31 Jan 2006
Rodenhiser David, Mann Mellissa
Abstract excerpt
Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. Research has shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates how genes are expressed. These mechanisms are critical components in the normal development and growth of cells. Epigenetic abnormalities have been found to be causative factors in...
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