Article
Epigenetic reprogramming and imprinting in origins of disease.
Reviews in endocrine & metabolic disorders - 1 Jun 2007
Tang Wan-yee, Ho Shuk-mei
Abstract excerpt
The traditional view that gene and environment interactions control disease susceptibility can now be expanded to include epigenetic reprogramming as a key determinant of origins of human disease. Currently, epigenetics is defined as heritable changes in gene expression that do not alter DNA sequence but are mitotically and transgenerationally inheritable. Epigenetic reprogramming is the process by which an...
Topics
- Acetylation
- Animals
- DNA Methylation
- Disease Susceptibility
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Genomic Imprinting
- Histones
- Humans
- Models, Biological
