Article
Association of beta2-adrenoceptor Gln27Glu variant with body weight but not hypertension.
American journal of hypertension - 1 Dec 2001
Lin RCY, Ericsson J O, Benjafield A V, Morris B J
Abstract excerpt
Beta2-adrenoceptor (beta2-ADR)-mediated vasodilatation decreases vascular reactivity and blood pressure (BP) and chromosome 5 where its gene (ADRB2R) resides and shows linkage to hypertension (HT). A Gln27Glu ADRB2R variant confers resistance to agonist-induced desensitization and enhanced vasodilator response to isoprenaline. Therefore, we carried out a case-control study in a cohort of HT and normotensive (NT)...
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