Article
Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets.
The Journal of infectious diseases - 1 Nov 2004
Herlocher M Louise, Truscon Rachel, Elias Stephanie, Yen Hui-Ling, Roberts Noel A, Ohmit Suzanne E, Monto Arnold S
Abstract excerpt
Three type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in the ferret model, an R292K mutant of a type A (H3N2) virus was not transmitted under conditions in which the wild-type virus was transmitted. This model was used to investigate whether the E119V mutant of a type A (H3N2) virus and...
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