Article
Dating the common ancestor of SIVcpz and HIV-1 group M and the origin of HIV-1 subtypes using a new method to uncover clock-like molecular evolution.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2001
Salemi M, Strimmer K, Hall W W, Duffy M, Delaporte E, Mboup S, Peeters M, Vandamme A M
Abstract excerpt
Attempts to estimate the time of origin of human immunodeficiency virus (HIV)-1 by using phylogenetic analysis are seriously flawed because of the unequal evolutionary rates among different viral lineages. Here, we report a new method of molecular clock analysis, called Site Stripping for Clock Detection (SSCD), which allows selection of nucleotide sites evolving at an equal rate in different lineages. The method...
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