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Article

Functional evaluation of mutations in the tissue-nonspecific alkaline phosphatase gene.

The Chinese journal of dental research - 1 Jan 2012

Zhu Tao, Gan Ye Hua, Liu He

Abstract excerpt

OBJECTIVE: To explore the relationship between the genotypes and phenotypes of these hypophosphatasia patients caused by gene mutations of tissue-nonspecific alkaline phosphatase (TNSALP). METHODS: Based on the genotypes of these patients, site-directed mutations of TNSALP cDNA at c.1162T>C or c.1120G>A or c.668G>A or c.535G>A were performed in the expression plasmids, respectively. The plasmids were transfected...

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PMID: 23509830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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