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Article

Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders.

The international journal of neuropsychopharmacology - 1 Jun 2005

Koido Kati, Kõks Sulev, Nikopensius Tiit, Maron Eduard, Altmäe Signe, Heinaste Evelin, Vabrit Kristel, Tammekivi Veronika, Hallast Pille, Kurg Ants, Shlik Jakov, Vasar Veiko, Metspalu Andres, Vasar Eero

Abstract excerpt

Wolfram syndrome gene (WFS1) has been suggested to have a role in the susceptibility for mood disorders. A 26-fold increased risk for psychiatric disorders in WFS1 mutation carriers has been suggested. In this study we tested the hypothesis that the WFS1 gene is related to the risk for mood disorders. We analysed 28 single-nucleotide polymorphisms (SNPs) of the WFS1 gene in 224 unrelated patients with major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15473915
DOI: 10.1017/S1461145704004791

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders.PMID 15473915Read ↗

WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder.Semantic proximity Read ↗

Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder.Semantic proximity Read ↗

No association between wolframin gene H611R polymorphism and mood disorders: evidence from 2,570 subjects.Semantic proximity Read ↗

No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans.Semantic proximity Read ↗

Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene.Semantic proximity Read ↗

The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders.Semantic proximity Read ↗

Wolfram syndrome in French population: characterization of novel mutations and polymorphisms in the WFS1 gene.Semantic proximity Read ↗

Association of aggression with a novel microRNA binding site polymorphism in the wolframin gene.Semantic proximity Read ↗

Wolframin mutations and hospitalization for psychiatric illness.Semantic proximity Read ↗

A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases.Semantic proximity Read ↗

Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.Semantic proximity Read ↗

Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.Semantic proximity Read ↗

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