Article
A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases.
Neuroscience letters - 24 Dec 1999
Furlong R A, Ho L W, Rubinsztein J S, Michael A, Walsh C, Paykel E S, Rubinsztein D C
Abstract excerpt
A recent report has shown that Wolfram syndrome carriers (heterozygotes) are 26-fold more likely to require psychiatric hospitalization compared with non-carriers, and that Wolfram syndrome heterozygotes may constitute approximately 25% of individuals hospitalized with depression and suicide attempts. We analyzed a His611Arg polymorphism of the wolframin gene by the polymerase chain reaction (PCR) and HhaI...
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