Article
The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders.
Psychiatric genetics - 1 Mar 2003
Martorell Lourdes, Zaera Montse Gómez, Valero Joaquín, Serrano Dolors, Figuera Lídia, Joven Jorge, Labad Antonio, Vilella Elisabet, Nunes Virginia
Abstract excerpt
BACKGROUND: Wolfram syndrome is a neurodegenerative disorder that is inherited in an autosomal recessive mode and characterized by the presence of diabetes mellitus and optic atrophy. Patients and heterozygote carriers are at an increased risk of suffering psychiatric disorders. Mutations in the Wolfram gene (WFS1 ) (4p16.1) are responsible for the development of the disease, and mRNA and protein expression of...
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