Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitro

28 Aug 2018

Abstract excerpt

P-glycoprotein (P-gp), a critical multidrug transporter, recognizes and transports various antiepileptic drugs (AEDs) through the blood-brain barrier (BBB). This may decrease the concentrations of AEDs in brain tissues and cause multidrug resistance (MDR) in patients with refractory epilepsy. Compelling evidence indicates that microRNAs (miRNAs) modulate MDR in various cancers by regulating P-gp expression....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to MicroRNA in disease regulation
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30210283
DOI: 10.3389/fnins.2018.00602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitroPMID 30210283Read ↗

P-glycoprotein (P-gp)-driven cancer drug resistance: biological profile, non-coding RNAs, drugs and nanomodulatorsSemantic proximity Read ↗

Significance of MDR1 and multiple drug resistance in refractory human epileptic brainSemantic proximity Read ↗

The Role of microRNAs in Multidrug Resistance of GlioblastomaSemantic proximity Read ↗

Long Non-coding RNA KCNQ1OT1 Contributes to Antiepileptic Drug Resistance Through the miR-138-5p/ABCB1 Axis in vitroSemantic proximity Read ↗

The network of P-glycoprotein and microRNAs interactionsSemantic proximity Read ↗

Role of ATP-Binding Cassette Transporter Proteins in CNS Tumors: Resistance- Based Perspectives and Clinical UpdatesSemantic proximity Read ↗

Regulation of multidrug resistance by microRNAs in anti-cancer therapySemantic proximity Read ↗

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer TreatmentSemantic proximity Read ↗

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological DiseasesSemantic proximity Read ↗

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAsSemantic proximity Read ↗

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human EpilepsySemantic proximity Read ↗

Circulating miRNAs expression profiling in drug-resistant epilepsy: Up-regulation of miR-301a-3p in a case of sudden unexpected deathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.