Article
Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene.
The Journal of clinical endocrinology and metabolism - 1 Oct 2004
Aschim Elin L, Nordenskjöld Agneta, Giwercman Aleksander, Lundin Kristina B, Ruhayel Yasir, Haugen Trine B, Grotmol Tom, Giwercman Yvonne L
Abstract excerpt
Although sufficient androgen receptor (AR) function is crucial for normal male sexual differentiation, single-point mutations in the AR gene are infrequent in the two most common male congenital malformations, hypospadias and cryptorchidism. Because polymorphic CAG and GGN segments regulate AR function, we investigated whether there was any association between these polymorphisms and mentioned malformations....
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