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Article

Inactivating mutations of the Siah-1 gene in gastric cancer.

Oncogene - 11 Nov 2004

Kim Chang Jae, Cho Yong Gu, Park Cho Hyun, Jeong Seong Whan, Nam Suk Woo, Kim Su Young, Lee Sug Hyung, Yoo Nam Jin, Lee Jung Young, Park Won Sang

Abstract excerpt

SIAH-1: is the mammalian homolog of Drosophila seven in absentia (sina) and has been identified as a p53-inducible gene. Siah-1 can induce cell cycle arrests, tumor suppression, and apoptosis through a novel beta-catenin degradation pathway. To determine whether genetic alterations of Siah-1 gene are involved in the development and/or progression of gastric cancer, we searched for mutation of the Siah-1 gene in...

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Identifiers

PMID: 15467739
DOI: 10.1038/sj.onc.1208113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Inactivating mutations of the Siah-1 gene in gastric cancer.PMID 15467739Read ↗

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Siah: A Promising Anticancer TargetSemantic proximity Read ↗

The phylogenetic functional conservation of <i>Drosophila</i> Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in <i>Drosophila</i> eye developmentSemantic proximity Read ↗

p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1Semantic proximity Read ↗

Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1Semantic proximity Read ↗

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia PathwaysSemantic proximity Read ↗

Reduced expression of RAS protein activator like-1 in gastric cancer.Semantic proximity Read ↗

Somatic mutations of BECN1, an autophagy-related gene, in human cancers.Semantic proximity Read ↗

Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoterSemantic proximity Read ↗

Expression and mutation analysis of TIG1 (tazarotene-induced gene 1) in human gastric cancer.Semantic proximity Read ↗

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