Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.

20 Aug 1996

Abstract excerpt

Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8799150
DOI: 10.1073/pnas.93.17.9039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.PMID 8799150Read ↗

p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1Semantic proximity Read ↗

The phylogenetic functional conservation of <i>Drosophila</i> Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in <i>Drosophila</i> eye developmentSemantic proximity Read ↗

Inhibition of RAS-Mediated Transformation and Tumorigenesis by Targeting the Downstream E3 Ubiquitin Ligase Seven in Absentia HomologueSemantic proximity Read ↗

Identification of p53 regulators by genome-wide functional analysis.Semantic proximity Read ↗

Atonal homolog 1 is a tumor suppressor gene.Semantic proximity Read ↗

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.Semantic proximity Read ↗

Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs.Semantic proximity Read ↗

Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene.Semantic proximity Read ↗

A genetic screen to identify components of the sina signaling pathway in Drosophila eye development.Semantic proximity Read ↗

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia PathwaysSemantic proximity Read ↗

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.Semantic proximity Read ↗

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.