Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemia

11 Mar 2024

Abstract excerpt

BACKGROUND: X-linked agammaglobulinemia (XLA) is an inborn error of immunity that renders boys susceptible to life-threatening infections due to loss of mature B cells and circulating immunoglobulins. It is caused by defects in the gene encoding the Bruton tyrosine kinase (BTK) that mediates the maturation of B cells in the bone marrow and their activation in the periphery. This paper reports on a gene editing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38479630
DOI: 10.1016/j.jaci.2024.03.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemiaPMID 38479630Read ↗

Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia.Semantic proximity Read ↗

Hematopoietic stem cell gene therapy for the treatment of X-linked agammaglobulinemiaSemantic proximity Read ↗

Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in manSemantic proximity Read ↗

X-Linked Agammaglobulinemia A Clinical and Molecular AnalysisSemantic proximity Read ↗

X-linked agammaglobulinemia: Twenty years of single-center experience from North West India.Semantic proximity Read ↗

Whole Genome Sequencing identifies novel structural variant in a large Indian family affected with X - linked agammaglobulinemiaSemantic proximity Read ↗

X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.Semantic proximity Read ↗

Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM SyndromeSemantic proximity Read ↗

PBMC-derived integration-free iPSCs line SDQLCHi039-A from a patient with X-linked agammaglobulinemia carrying a novel 9-bp in-frame deletion in BTK gene.Semantic proximity Read ↗

Characterization of Bruton's tyrosine kinase mutations in Mexican patients with X-linked agammaglobulinemia.Semantic proximity Read ↗

Splice-correction strategies for treatment of X-linked agammaglobulinemia.Semantic proximity Read ↗

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.