Article
Syncollin is required for efficient zymogen granule exocytosis.
The Biochemical journal - 1 Feb 2005
Wäsle Barbara, Turvey Matthew, Larina Olga, Thorn Peter, Skepper Jeremy, Morton A Jennifer, Edwardson J Michael
Abstract excerpt
Syncollin is a 13 kDa protein that is present in the exocrine pancreas, where the majority of the protein is tightly attached to the luminal surface of the zymogen granule membrane. We have addressed the physiological role of syncollin by studying the phenotype of syncollin KO (knockout) mice. These mice show pancreatic hypertrophy and elevated pancreatic amylase levels. Further, secretagogue-stimulated amylase...
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