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Article

Mediation of Af4 protein function in the cerebellum by Siah proteins.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 2004

Oliver Peter L, Bitoun Emmanuelle, Clark Joanne, Jones Emma L, Davies Kay E

Abstract excerpt

We have established that the gene AF4, which had long been recognized as disrupted in childhood leukemia, also plays a role in the CNS. Af4 is mutated in the robotic mouse that is characterized by ataxia and Purkinje cell loss. To determine the molecular basis of this mutation, we carried out a yeast two-hybrid screen and show that Af4 binds the E3 ubiquitin ligases Drosophila seven in absentia (sina) homologues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15459319
DOI: 10.1073/pnas.0406196101
PMCID: PMC522018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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