Article
A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor.
The Journal of biological chemistry - 17 Dec 2004
Zhu Li, Jang Geeng-Fu, Jastrzebska Beata, Filipek Slawomir, Pearce-Kelling Susan E, Aguirre Gustavo D, Stenkamp Ronald E, Acland Gregory M, Palczewski Krzysztof
Abstract excerpt
Rho (rhodopsin; opsin plus 11-cis-retinal) is a prototypical G protein-coupled receptor responsible for the capture of a photon in retinal photoreceptor cells. A large number of mutations in the opsin gene associated with autosomal dominant retinitis pigmentosa have been identified. The naturally occurring T4R opsin mutation in the English mastiff dog leads to a progressive retinal degeneration that closely...
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