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Article

Differential Aggregation Properties of Mutant Human and Bovine Rhodopsin.

Biochemistry - 12 Jan 2021

Vasudevan Sreelakshmi, Park Paul S-H

Abstract excerpt

Rhodopsin is the light receptor required for the function and health of photoreceptor cells. Mutations in rhodopsin can cause misfolding and aggregation of the receptor, which leads to retinal degeneration. Bovine rhodopsin is often used as a model to understand the effect of pathogenic mutations in rhodopsin due to the abundance of structural information on the bovine form of the receptor. It is unclear whether...

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PMID: 33356167
DOI: 10.1021/acs.biochem.0c00733
PMCID: PMC7863732

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