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Article

Spermine synthesis is required for normal viability, growth, and fertility in the mouse.

The Journal of biological chemistry - 3 Dec 2004

Wang Xiaojing, Ikeguchi Yoshihiko, McCloskey Diane E, Nelson Paul, Pegg Anthony E

Abstract excerpt

Spermidine is essential for viability in eukaryotes but the importance of the longer polyamine spermine has not been established. Spermine is formed from spermidine by the action of spermine synthase, an aminopropyltransferase, whose gene (SpmS) is located on the X chromosome. Deletion of part of the X chromosome that include SpmS in Gy mice leads to a striking phenotype in affected males that includes altered...

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Identifiers

PMID: 15459188
DOI: 10.1074/jbc.M410471200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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