Article
Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock.
American journal of physiology. Heart and circulatory physiology - 1 Feb 2005
Binck Brian W, Tsen May F, Islas Miguel, White D Jean, Schultz Roger A, Willis Monte S, Garcia J Victor, Horton Jureta W, Thomas James A
Abstract excerpt
How infection precipitates depressed contractility is incompletely understood but may involve the immune, nervous, and endocrine systems as well as the heart itself. In this study, we examined the role of Toll-like receptor 4 (TLR4) in LPS-induced myocardial contractile depression. Eighteen hours following endotoxin challenge, we compared contractile responses in hearts from wild-type (WT) and TLR4-deficient mice...
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