Article
Human leukocyte antigen class II and cervical cancer risk: a population-based study.
The Journal of infectious diseases - 1 Dec 2002
Madeleine Margaret M, Brumback Babette, Cushing-Haugen Kara L, Schwartz Stephen M, Daling Janet R, Smith Anajane G, Nelson J Lee, Porter Peggy, Shera Katherine A, McDougall James K, Galloway Denise A
Abstract excerpt
The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II DRB1 and DQB1 genes were examined in 315 women with invasive squamous cell cervical cancer (SCC) and 381 control subjects. Increased risks of SCC were associated with DRB1*1001,...
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