Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.

doi:10.1002/art.34429

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Article

Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.

Arthritis and rheumatism - 1 Aug 2012

Thompson Susan D, Marion Miranda C, Sudman Marc, Ryan Mary, Tsoras Monica, Howard Timothy D, Barnes Michael G, Ramos Paula S, Thomson Wendy, Hinks Anne, Haas Johannes-Peter, Prahalad Sampath, Bohnsack John F, Wise Carol A, Punaro Marilynn, Rosé Carlos D, Pajewski Nicholas M, Spigarelli Michael, Keddache Mehdi, Wagner Michael, Langefeld Carl D, Glass David N

Abstract excerpt

OBJECTIVE: In a genome-wide association study of Caucasian patients with juvenile idiopathic arthritis (JIA), we have previously described findings limited to autoimmunity loci shared by JIA and other diseases. The present study was undertaken to identify novel JIA-predisposing loci using genome-wide approaches. METHODS: The discovery cohort consisted of Caucasian JIA cases (n = 814) and local controls (n = 658)...

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PMID: 22354554
DOI: 10.1002/art.34429
PMCID: PMC3366043

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