Neonatal lupus erythematosus syndrome: analysis of C4 allotypes and C4 genes in 18 families.

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Article

Neonatal lupus erythematosus syndrome: analysis of C4 allotypes and C4 genes in 18 families.

Medicine - 1 Mar 1992

Watson R M, Scheel J N, Petri M, Lee L A, Bias W B, McLean R H

Abstract excerpt

We examined 18 families with infants who had neonatal lupus erythematosus (NLE) syndrome to determine whether abnormalities in C4 phenotypes and genotypes were an additional risk factor for this syndrome. Fifteen of 18 mothers of infants with NLE (83%) had C4 null allotypes compared with 36% of p...

Topics

Antibodies, Antinuclear
Chromosome Deletion
Complement C4
Female
Genotype
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Heart Block
Histocompatibility Testing
Humans
Infant, Newborn
Lupus Erythematosus, Cutaneous
Male
Multigene Family
Pedigree
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1545698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1545698-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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