Article
Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse.
The Journal of biological chemistry - 3 Dec 2004
Fueger Patrick T, Hess Holli S, Posey Kelly A, Bracy Deanna P, Pencek R Richard, Charron Maureen J, Wasserman David H
Abstract excerpt
Previous work suggests that normal GLUT4 content is sufficient for increases in muscle glucose uptake (MGU) during exercise because GLUT4 overexpression does not increase exercise-stimulated MGU. Instead of glucose transport, glucose phosphorylation is a primary limitation of exercise-stimulated MGU. It was hypothesized that a partial ablation of GLUT4 would not impair exercise-stimulated MGU when glucose...
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