Article
[Methylation of promoter region of RASSF1A gene and frequencies of allelic imbalances in chromosome 3 critical regions are correlated with progression of clear cell renal cell carcinoma].
Molekuliarnaia biologiia - 1 Jan 2000
Loginov V I, Khodyrev D S, Pronina I V, Kazubskaia T P, Ermilova V D, Gar'kavtseva R F, Braga E A
Abstract excerpt
The short arm of chromosome 3 (3p) contains several critical regions harboring the set of genes with tumor suppressor activities. The RASSF1A gene (LUCA region, 3p21.31) shows various functions which can be associated with tumorigenesis. Among 3p genes this gene can be most frequently methylated in epithelial tumors of various locations. Here two independent methods (methyl-specific PCR and methyl-sensitive...
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