Article
Construction, training and clinical validation of an interpretation system for genotypic HIV-1 drug resistance based on fuzzy rules revised by virological outcomes.
Antiviral therapy - 1 Aug 2004
De Luca Andrea, Vendittelli Marilena, Baldini Francesco, Di Giambenedetto Simona, Trotta Maria Paola, Cingolani Antonella, Bacarelli Alessandra, Gori Caterina, Perno Carlo Federico, Antinori Andrea, Ulivi Giovanni
Abstract excerpt
OBJECTIVES: To evaluate whether fuzzy operators can be usefully applied to the interpretation of genotypic HIV-1 drug resistance by experts, and to improve the prediction of salvage therapy outcome by adapting interpretation rules of genotypic resistance on the basis of their association with virological response data. METHODS: We used a clinical dataset of 231 patients failing highly active antiretroviral...
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