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Article

Quantifying dominance and deleterious effect on human disease genes.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2009

Osada Naoki, Mano Shuhei, Gojobori Jun

Abstract excerpt

Human genes responsible for inherited diseases are important for the understanding of human disease. We investigated the degree of polymorphism and divergence in the human disease genes to elucidate the effect of natural selection on human disease genes. In particular, the effect of disease dominance was incorporated into the analysis. Both dominant disease genes (DDG) and recessive disease genes (RDG) had a...

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Share to Genes, Dominant
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19139396
DOI: 10.1073/pnas.0810433106
PMCID: PMC2630084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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