Article
Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jan 2000
Gemmati Donato, Tognazzo Silvia, Serino Maria L, Fogato Luisella, Carandina Sergio, De Palma Massimiliano, Izzo Marcello, De Mattei Monica, Ongaro Alessia, Scapoli Gian L, Caruso Angelo, Liboni Alberto, Zamboni Paolo
Abstract excerpt
Low Factor XIII (FXIII) activity has been reported in the blood of patients with chronic venous leg ulcer (CVU). In vivo studies have described increased wound healing in CVU patients treated with FXIII concentrate, and in vitro studies have shown increased regenerative capacity in FXIII-treated fibroblasts. In addition, a common G-to-T polymorphism in the FXIIIA-subunit gene (V34L) significantly increases the...
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