Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay of iron metallobiology, metalloproteinases, and FXIII, and role of their gene variants in venous leg ulcer.

The international journal of lower extremity wounds - 1 Dec 2010

Singh Ajay V, Subhashree L, Milani Paolo, Gemmati Donato, Zamboni Paolo

Abstract excerpt

The iron metallobiology has long been suspected as a causal agent in venous leg ulcer (VLU) pathophysiology. However, it was demonstrated only recently that visible iron deposits cause lesions in only some individuals due to functional iron and related gene variants. In this article, the mechanism by which dysregulated iron cycle leads to local iron overload that could generate free radicals or activate a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor XIII

Share to Iron Overload

Share to Metalloproteases

Share to Reactive Oxygen Species

Share to Wound Healing

Source

Identifiers

PMID: 21118859
DOI: 10.1177/1534734610384653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay of iron metallobiology, metalloproteinases, and FXIII, and role of their gene variants in venous leg ulcer.PMID 21118859Read ↗

Clinical implications of gene polymorphisms in venous leg ulcer: A model in tissue injury and reparative processSemantic proximity Read ↗

The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis.Semantic proximity Read ↗

Commentary on "The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis".Semantic proximity Read ↗

Potential Mechanism of HXSJ Decoction in the Treatment of Venous Leg Ulcer: Based on the Association between Venous Leg Ulcers and FerroptosisSemantic proximity Read ↗

Evaluation of physiological risk factors, oxidant-antioxidant imbalance, proteolytic and genetic variations of matrix metalloproteinase-9 in patients with pressure ulcer.Semantic proximity Read ↗

Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension.Semantic proximity Read ↗

Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review.Semantic proximity Read ↗

Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers.Semantic proximity Read ↗

Factor XIII-A in Diseases: Role Beyond Blood Coagulation.Semantic proximity Read ↗

Inflammation in venous disease.Semantic proximity Read ↗

DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators.Semantic proximity Read ↗

Mutating factor VIII: lessons from structure to function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.