Article
Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers.
Journal of vascular surgery - 1 Oct 2006
Tognazzo Silvia, Gemmati Donato, Palazzo Annunziata, Catozzi Linda, Carandina Sergio, Legnaro Andrea, Tacconi Giovanna, Scapoli Gian L, Zamboni Paolo
Abstract excerpt
OBJECTIVE: Many factors impair healing of chronic venous ulcer (CVU), and many theories have been proposed to explain their pathogenesis. Coagulation factor XIII (FXIII) influences tissue regeneration and angiogenesis with effects on wound healing. Because FXIII properties depend upon its genetic variants, we investigated whether intragene polymorphisms may have modulating effects on the CVU area. METHODS: The...
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