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Article

Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.

Molecular psychiatry - 1 May 2005

Thomson P A, Wray N R, Thomson A M, Dunbar D R, Grassie M A, Condie A, Walker M T, Smith D J, Pulford D J, Muir W, Blackwood D H R, Porteous D J

Abstract excerpt

GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD). Allele frequencies of three polymorphisms in GPR50 were compared in case-control studies between subjects with BPAD (264), major depressive disorder (MDD) (226), or schizophrenia (SCZ) (263) and ethnically matched controls (562). Significant...

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Share to Bipolar Disorder
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Nerve Tissue Proteins

Share to Receptors, G-Protein-Coupled

Share to Schizophrenia

Share to Sex Characteristics

Share to Statistics, Nonparametric

Source

Identifiers

PMID: 15452587
DOI: 10.1038/sj.mp.4001593

Genes

GPR50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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