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Article

Clonal Selection for Transcriptionally Active Viral Oncogenes during Progression to Cancer

27 Sept 2004

Abstract excerpt

Primary keratinocytes immortalized by human papillomaviruses (HPVs), along with HPV-induced cervical carcinoma cell lines, are excellent models for investigating neoplastic progression to cancer. By simultaneously visualizing viral DNA and nascent viral transcripts in interphase nuclei, we demonstrated for the first time a selection for a single dominant papillomavirus transcription center or domain (PVTD)...

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PMID: 15452237
DOI: 10.1128/jvi.78.20.11172-11186.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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