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Article

Single point mutation in tick-borne encephalitis virus prM protein induces a reduction of virus particle secretion

24 Sept 2004

Abstract excerpt

Flaviviruses are assembled to bud into the lumen of the endoplasmic reticulum (ER) and are secreted through the vesicle transport pathway. Virus envelope proteins play important roles in this process. In this study, the effect of mutations in the envelope proteins of tick-borne encephalitis (TBE) virus on secretion of virus-like particles (VLPs), using a recombinant plasmid expression system was analysed. It was...

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PMID: 15448368
DOI: 10.1099/vir.0.80169-0

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