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Article

Mutations in the West Nile prM protein affect VLP and virion secretion in vitro.

Virology - 10 Nov 2012

Calvert Amanda E, Huang Claire Y-H, Blair Carol D, Roehrig John T

Abstract excerpt

Mutation of the West Nile virus-like particle (WN VLP) prM protein (T20D, K31A, K31V, or K31T) results in undetectable VLP secretion from transformed COS-1 cells. K31 mutants formed intracellular prM-E heterodimers; however these proteins remained in the ER and ER-Golgi intermediary compartments of transfected cells. The T20D mutation affected glycosylation, heterodimer formation, and WN VLP secretion. When...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22858174
DOI: 10.1016/j.virol.2012.07.011
PMCID: PMC5812725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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