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Article

Telomerase levels control the lifespan of human T lymphocytes

15 Apr 2003

Abstract excerpt

The loss of telomeric DNA with each cell division contributes to the limited replicative lifespan of human T lymphocytes. Although telomerase is transiently expressed in T lymphocytes upon activation, it is insufficient to confer immortality. We have previously shown that immortalization of human CD8+ T lymphocytes can be achieved by ectopic expression of the human telomerase reverse transcriptase (hTERT) gene,...

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Identifiers

PMID: 12689947
DOI: 10.1182/blood-2002-07-2015

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