Article
9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells.
Differentiation; research in biological diversity - 1 Sept 1993
Kurie J M, Buck J, Eppinger T M, Moy D, Dmitrovsky E
Abstract excerpt
Prior work has shown that all-trans retinoic acid (t-RA) treatment of the human teratocarcinoma (TC) cell line NTERA-2 clone D1 (abbreviated NT2/D1) induces a neuronal phenotype and other cell lineages. This study sought to explore the potential of 9-cis retinoic acid (9-cis RA) as a differentiation-inducing agent of this multipotent cell. Findings reported here show that 9-cis RA induced a phenotype similar to...
Topics
- Cell Differentiation
- Drug Resistance
- Humans
- Neurons
- Phenotype
- Receptors, Retinoic Acid
- Stereoisomerism
- Teratocarcinoma
- Tretinoin
- Tumor Cells, Cultured