Article
Hydrolink gels: a rapid and simple approach to the detection of DNA mutations in thromboembolic disease.
Journal of clinical pathology - 1 Feb 1992
Perry D J, Carrell R W
Abstract excerpt
AIMS: To develop a simple and rapid technique for detecting DNA mutations based on the polymerase chain reaction, followed by electrophoresis, in a novel polymer--Hydrolink D5000--specifically designed to separate double stranded DNA fragments. METHODS: Eleven subjects with previously characterised mutations within the antithrombin gene (including single base pair mutations and insertions) and three normal...
Topics
- Antithrombins
- DNA
- Electrophoresis
- Gels
- Gene Amplification
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymers
- Thromboembolism