Haemoglobin Köln as de novo mutations in Sweden: diagnosis by PCR and specific enzymatic cleavage.

doi:10.1111/j.1600-0609.1994.tb01307.x

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Article

Haemoglobin Köln as de novo mutations in Sweden: diagnosis by PCR and specific enzymatic cleavage.

European journal of haematology - 1 Mar 1994

Landin B, Fröstad B, Brune M, Ljung R

Abstract excerpt

Three independent cases of chronic haemolytic anaemia in Sweden have recently been demonstrated to be due to the unstable haemoglobin variant Hb Köln. The patients, all of whom have partially compensated chronic haemolytic anaemia, presented with aggravated haemolysis during acute infections in c...

Topics

Adult
Amino Acid Sequence
Anemia, Hemolytic, Congenital
Base Sequence
Child
DNA Primers
Female
Globins
Hemoglobins, Abnormal
Humans
Infant
Male
Molecular Sequence Data
Mutation
Pedigree
Restriction Mapping

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