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Genetic diagnosis of factor V Leiden using heteroduplex technology.

Thrombosis and haemostasis - 1 Jan 1997

Bowen D J, Standen G R, Granville S, Bowley S, Wood N A, Bidwell J

Abstract excerpt

A new genetic test has been developed for detection of the mutation known as factor V Leiden. The test employs heteroduplex technology and comprises a single PCR reaction followed immediately by PCR product analysis. It therefore represents the minimum practical route from blood/tissue sample to genetic result. A cohort of 100 patients with a history of thrombosis have been screened using both the new...

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PMID: 9031460

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