Article
A spontaneous chromosomal amplification of the ADH2 gene in Saccharomyces cerevisiae.
Genetics - 1 Feb 1992
Paquin C E, Dorsey M, Crable S, Sprinkel K, Sondej M, Williamson V M
Abstract excerpt
A spontaneous antimycin A-resistant mutant carrying approximately four extra copies of ADH2 on chromosome XII was isolated from yeast strain 315-1D which lacks a functional copy of ADH1 and thus is antimycin A-sensitive. The additional copies of the normally glucose-repressed ADH2 are expressed d...
Topics
- Alcohol Dehydrogenase
- Antimycin A
- Base Sequence
- Chromosomes, Fungal
- Cloning, Molecular
- DNA, Fungal
- DNA, Ribosomal
- Drug Resistance, Microbial
- Gene Amplification
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Restriction Mapping
- Saccharomyces cerevisiae