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Article

A spontaneous chromosomal amplification of the ADH2 gene in Saccharomyces cerevisiae.

Genetics - 1 Feb 1992

Paquin C E, Dorsey M, Crable S, Sprinkel K, Sondej M, Williamson V M

Abstract excerpt

A spontaneous antimycin A-resistant mutant carrying approximately four extra copies of ADH2 on chromosome XII was isolated from yeast strain 315-1D which lacks a functional copy of ADH1 and thus is antimycin A-sensitive. The additional copies of the normally glucose-repressed ADH2 are expressed during growth on glucose accounting for the antimycin A resistance. These extra copies are inserted into nonadjacent...

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Identifiers

PMID: 1541390
DOI: 10.1093/genetics/130.2.263
PMCID: PMC1204847

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