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Article

Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces.

Genetics - 1 May 1990

Leppert G, McDevitt R, Falco S C, Van Dyk T K, Ficke M B, Golin J

Abstract excerpt

Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the unrelated inhibitor, sulfometuron methyl, due to a plasmid-borne resistance determinant. The...

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Identifiers

PMID: 2160400
DOI: 10.1093/genetics/125.1.13
PMCID: PMC1203995

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