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Article

Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes.

Genetic epidemiology - 1 Nov 2004

Yu K, Gu C Charles, Province M, Xiong C J, Rao D C

Abstract excerpt

Taking advantage of increasingly available high-density single nucleotide polymorphism (SNP) markers within genes and across genomes, more and more genetic association studies began to use multiple closely linked markers in candidate genes. A practical analytical challenge arising in such studies is the possibility that not all case chromosomes have inherited disease-causing mutations from a common ancestral...

Topics

Alleles
Case-Control Studies
Chromosome Mapping
Founder Effect
Genetic Heterogeneity
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical

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Identifiers

PMID: 15389925
DOI: 10.1002/gepi.20022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15389925-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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