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Article

Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries

22 Apr 2004

Abstract excerpt

BACKGROUND: Prostase/KLK4 is a member of the human kallikrein (KLK) gene family that is expressed in prostate epithelial cells under the regulation of androgenic hormones. In this study, we sought to characterize the substrate specificity of KLK4 in order to gain insight into potential physiological roles of the enzyme. METHODS: A chimeric form of KLK4 was constructed in which the pro-region of KLK4 was replaced...

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Share to Blood Coagulation and Thrombosis Mechanisms
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PMID: 15389820
DOI: 10.1002/pros.20101

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