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Article

Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance

6 Apr 2012

Abstract excerpt

Tissue kallikrein (KLK1) and kallikrein-related peptidases (KLK2-15) comprise a family of 15 highly conserved secreted serine proteases with similar structural characteristics and a wide spectrum of functional properties. Both gene expression and protein activity of KLKs are rigorously controlled at various levels via diverse mechanisms, including extensive steroid hormone regulation, to exert their broad...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

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PMID: 22505514
DOI: 10.1515/hsz-2011-0260

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