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Article

Evolutionary History of Tissue Kallikreins

1 Nov 2010

Abstract excerpt

The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and pleiotropic functions in normal physiology as well as in disease states. Currently, the most widely known KLK is KLK3 or prostate-specific antigen (PSA) that has applications in clinical diagnosis and monitoring of prostate cancer. The KLK gene family encompasses the largest contiguous cluster of serine proteases in...

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PMID: 21072173
DOI: 10.1371/journal.pone.0013781

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