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Article

Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1.

Journal of cellular physiology - 1 Jan 2005

Zhang Xuefeng, Groopman Jerome E, Wang Jian Feng

Abstract excerpt

Endothelium extracellular matrix (ECM) interactions can provide distinct spatial and molecular signals which control cellular proliferation, migration, and differentiation. Here, we investigated the role of fibronectin (FN), a major ECM protein, on the functions of lymphatic endothelial cells (LEC). We observed that FN, the ligand for integrin alpha5beta1, selectively promoted the growth of LEC as compared with...

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Source

Identifiers

PMID: 15389531
DOI: 10.1002/jcp.20106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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