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Molecular Determinants of Treatment Response in Acute Lymphoblastic Leukemia

1 Jan 2008

Abstract excerpt

Treatment response in patients with acute lymphoblastic leukemia (ALL) is best assessed using assays for minimal residual disease (MRD). The degree of leukemia cytoreduction and MRD clearance is determined by the collective influence of multiple factors. Some of these variables are features of the leukemic cells, such as expression of genes that regulate their susceptibility to cytotoxic drugs and their...

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PMID: 19074112
DOI: 10.1182/asheducation-2008.1.366

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