Article
A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension.
Molecular microbiology - 1 Sept 2004
Ellis James, Sarkar Mitali, Hendriks Edward, Matthews Keith
Abstract excerpt
The protozoan parasite Trypanosoma brucei undergoes a complex developmental cycle coordinated with cell cycle control. These processes in eukaryotes are frequently regulated through mitogen-activated protein kinases (MAPKs) and cyclin-dependent protein kinases (CDKs), respectively. We have discovered a novel protein kinase which shares features of both ERK-type MAPKs and CDKs (T. brucei ERK-like, CDK-like protein...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Cell Cycle
- Cell Proliferation
- Cyclin-Dependent Kinases
- Extracellular Signal-Regulated MAP Kinases
- Gene Expression Regulation
- Molecular Sequence Data
- Mutation