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Article

Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival.

PloS one - 1 Jan 2013

Boynak Natalia Y, Rojas Federico, D'Alessio Cecilia, Vilchez Larrea Salomé C, Rodriguez Vanina, Ghiringhelli Pablo D, Téllez-Iñón María T

Abstract excerpt

Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a key regulator of cell cycle sequence during G2/M transition and inhibits mitotic entry by phosphorylating the inhibitory tyrosine 15 on the cdc2 M-phase-inducing...

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Identifiers

PMID: 24223931
DOI: 10.1371/journal.pone.0079364
PMCID: PMC3818516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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